The plane, a Piper PA-28 aircraft, took off from Blairstown Airport and was headed to Sky Manor Airport when it crashed about a half-mile northeast of the airport, near Pittstown.
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It happened around 10:45 p.m. Saturday.
When first responders arrived, they found the plane covered in flames and quickly began helping the three on board.
The pilot, Kyle Dalrymple, and two passengers, Clinton Campbell and Wendy Race, were conscious and out of the plane when responders arrived.
A foam line was used to attack the blaze.
The passengers were airlifted to trauma centers in Morristown. Their conditions are not yet known.
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It's unclear whether the plane was taking off or landing.
The crash is under investigation by the FAA and the NTSB.
(The Associated Press contributed to this report.)