The incident happened on Lower Swiftwater Road near Route 611 in Pocono Township.
The woman, who has not been identified, drove over a gas line that was buried under a road, which triggered the explosion.
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There were three other people in the car, including a 3-year-old child who survived the blast and will be OK.
A man in the car was also injured.
The company that owns the gas line says there was no indication of an explosion involving its main or associated equipment.
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