Dozens of cops responded to the scene in front of a TD Bank at 42nd Street and 9th Ave just after 1 p.m.
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According to investigators, an 18-year-old got into a fight with an unknown person.
A second person then fired one shot at the teenager.
Police say they are looking for 31-year-old Eric Raheem and an unidentified woman.
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She was described as 5'5" to 5'7" tall, heavy build, wearing a dark blue hooded bubble jacket, blue sweatpants, black or grey boots and armed with a silver firearm.
The 18-year-old was not seriously injured.
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