The flames broke out around 6 a.m. on Cedar Street on the third floor.
Yonkers Fire Department said there was heavy flames shooting out of the windows upon arrival.
Firefighters began battling the flames inside as they searched for the home's occupants.
The fire then spread to a neighboring home.
A 28-year old man died in the fire. His identity has not yet been released. The conditions of the two people hurt are not yet known.
The cause of the fire is under investigation.
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