The victims, who both appeared to be in their 30s, were found outside Urban Pathways, a nonprofit that helps the homeless, on Ninth Avenue just after 4:45 a.m.
One of the men was stabbed multiple times in the torso and was pronounced dead at Bellevue Hospital.
The other was stabbed multiple times in the abdomen and is in stable condition.
A suspect, last seen wearing a blue jacket and blue pants, fled southbound on Ninth Avenue on a bicycle.
No arrests were immediately made and there is no known motive.
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