The fire broke out on the third floor of the apartment building on 35th Street just after 10:50 p.m. on Thursday.
A woman in her 90s was found unconscious and unresponsive. She was rushed to Mount Sinai Queens, where she was pronounced dead.
Another woman, a 61-year-old, was taken to Jacobi Hospital in critical condition
The cause of the fire is under investigation.
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