The victims, a man and a woman, were on a scooter that collided with an SUV near the Jackie Robinson Parkway at around 6:35 p.m.
They struck a white BMW, a blue Ford Explorer and a Black Ford van as they were ejected onto the highway.
Police say the male victim died at the scene. The woman was later pronounced dead at NY-Presbyterian Queens Hospital.
The drivers of the three other vehicles were taken to hospitals and are in stable condition.
Police have not yet released the identity of the victims.
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