The purses, each worth around $10,000, were taken when the suspects broke through the front window of the store on Madison at 64th Street at around 7 p.m. Sunday.
According to investigators, the total value of the stolen bags is $32,400.
The men fled on foot.
There is no immediate description or arrests but police were recovering surveillance video from the store.
On Monday morning, the store was all boarded up.
One resident Eyewitness News spoke to, said they weren't very surprised.
"That's pretty crazy and that's scary, but honestly, it's New York, so I've seen it all," the resident said. "It really doesn't phase me sadly but it does kind of creep you out a little bit at least."
The Madison Avenue Business Improvement District released a statement saying in part that with all of the cameras in the area, they are confident police will make a swift arrest.
The NYPD says burglaries are down 7% across the city from last year and are down 15% in the 19th Precinct.
Anyone with information is asked to contact the police.
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