Video shows firefighters on the scene as heavy flames shot out of the two-story home on 68th Avenue in Douglaston just after midnight on Saturday.
According to the FDNY, more than 60 firefighters responded.
One civilian and a firefighter suffered minor injuries and were transported to North Shore University Hospital for treatment. Another person refused medical attention on the scene.
The fire was put under control about an hour later.
Authorities are trying to determine the cause of the fire.
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