The fire completely shut down the northbound side of the turnpike on the inner roadway north of interchange 12.
The two-tractor trailers collided around 3:30 a.m. and became fully engulfed. One of the trucks was carrying lumber.
Traffic was at a complete standstill near the scene for several hours.
It's not expected to reopen for some time while crews work to extinguish the fire.
The extent of the injuries to those involved is not yet known.
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