The crash happened around 7:40 p.m. at Lenox Avenue and West 135th Street.
Police a 37-year-old woman, 4-month-old girl, 2-year-old girl and a 3-year-old girl were crossing the street when a Nissan SUV traveling southbound on Lenox Avenue turned onto West 135th Street and struck the 2- and 3-year-old girls.
The 40-year-old man who was driving the vehicle got out of his car, picked up the 3-year-old girl and carried her to NYC Health & Hospitals/ Harlem, where she later died. The 2-year-old girl was also taken to the hospital.
The 37-year-old woman, 40-year-old driver and the 4-month-old were not injured.
It's unclear what the relationships are between the woman and the three children.
The investigation remains ongoing.
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