The fire started at Kearny Steel Container, part of a South Street industrial complex, just after 12:30 a.m.
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The commercial building where the fire began houses steel and plastic containers, and other work materials. The warehouse contained combustible materials, which was also a concern.
Fire quickly spread to an adjacent building, trailers and cars parked outside. A transformer explosion ignited a third building.
It took firefighters time to gain entry due to obstructions and a partial building collapse. About 120 responded and they also had water and electrical problems.
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The fire reached four alarms before it was contained. It was hours before the fire could be knocked down.
Kearny was open Tuesday for business, but only on a limited basis. It's still not clear when employees will be able to return to work.
The cause of the fire is now under investigation. No injuries were reported.