The accident happened at East 162nd Street and Washington Avenue in the Morrisania section.
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Police say that at about 3 p.m., officers saw a vehicle commit a traffic violation.
When they tried to pull the car over, the driver attempted to flee, ran a red light, and T-boned a vehicle, then hit another vehicle.
Five people were inside the first vehicle that was struck and one was in the second. All were hospitalized with minor injuries.
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Two people in the car that was being chased were taken into custody. A 20-year-old man was charged with gun possession and a 29-year-old is being questioned.
One more person is still being sought.
Police say a gun was recovered at the scene.
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