Police responded around 3:15 p.m. to 751 Monroe Street, where they found the 54-year-old man with a gunshot wound to the chest.
First responders transported the victim in critical condition to Kings County Hospital, where he died a short time later.
According to the NYPD, the suspect was last seen fleeing on foot in a ski mask and khaki pants.
Investigators are still trying to determine the motive for the shooting.
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