It happened on Sunday on E. 81 Street in Canarsie.
Police say the 47-year-old mother was stabbed in the neck. She was pronounced dead after being transported to the hospital.
The woman's 15-year-old son was slashed in the hand. Police say he remains in stable condition.
The NYPD says the incident was a case of domestic violence, and the attacker might be a relative of the mother and son.
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