Smoke could be seen billowing out of several smashed windows as firefighters worked to control the blaze.
Investigators say the flames started on the fifth floor around 8 a.m. on Saturday. 60 FDNY and EMS personnel responded to the scene.
The two injured firefighters were transported to Lenox Hill Hospital for treatment.
Fire marshals are investigating, as the cause of the fire is still unknown.
This is a developing story. Please check back for updates.
* Get Eyewitness News Delivered
* Follow us on YouTube
* More local news
* Send us a news tip
* Download the abc7NY app for breaking news alerts