It happened shortly before 6 p.m. at 2382 Webster Ave. in the Fordham Heights section.
Officials say a 36-year-old man suffered multiple gunshot wounds throughout his body, and a 34-year-old woman suffered a graze wound to her leg.
Both victims were taken to St. Barnabas Hospital in stable condition.
Police are searching for a male wearing a black sweatshirt and a skin mask who fled on 187th Street.
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