It happened on East 187th Street between Belmont and Cambreleng avenues.
The FDNY said the fire was on multiple floors of the five-story building.
The building is home to a barbershop and deli on the ground floor as well as an apartment building.
Officials say two people were killed, two suffered serious injuries, another two suffered minor injuries and five firefighters also suffered minor injuries.
Few other details were released.
This story will be updated as more information becomes available.
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