It happened on Union Turnpike and 175th Street right outside of St. John's University just before 9 p.m.
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It appears that the car hit the bus head-on when it turned out of an exit at the university onto a divided road on the wrong side.
The MTA says that the bus driver likely survived thanks to the A-pillar design of the bus.
There were fireworks going on at the time of the crash due to a winter celebration at St. John's. One student Eyewitness News spoke to suggested the driver may have gotten distracted.
The driver of the Q46 bus and a passenger suffered minor injuries and were taken to Queens Hospital.
Authorities are investigating the cause of accident.