It happened around 10 p.m. Wednesday in the westbound lanes of Route 17, just past the Phillipsburg Road overpass in Goshen.
A car was driving the wrong way when it crashed head-on into the tractor-trailer.
The car caught fire and then spread to the cab of the tractor-trailer.
There driver of the car died. There is no word on the condition of the truck driver.
New York State Police have not yet determined the cause of the crash.
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