The robbery happened just before 9:30 p.m. on Thursday.
Police say the burglar broke the front glass window with a pole, then grabbed two purses, a vanity case, a wallet and a card holder before fleeing on foot eastbound on East 65th Street toward Park Avenue.
The merchandise is said to be worth about $12,000.
The suspect is described by police as a man in his 30's with a black beard, approximately 6'2", and 200 pounds.
He was last seen wearing black jogging clothes, a white vest, a white baseball hat and black sandals.
No arrests have been made, and the investigation is ongoing.
This is the same Chanel store broken into last October by two men with sledgehammers.
During that robbery, the pair stole purses with a total value of more than $30,000.
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