Of the 709 faculty members of Arts and Sciences at Columbia University, 65% voted in favor of no confidence, 29% were against it, and about 6% abstained.
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The Faculty of Arts and Sciences makes up a fifth of the university's full-time faculty body.
The motion was brought by members of the university's chapter of the American Association of University Professors.
Voting began on May 8 and concluded on Wednesday.
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The vote was prompted by concerns about the state of shared governance and academic freedom at the university, specifically, Shafik's decision to call police onto campus twice to clear pro-Palestinian protests.
A spokesperson for the university says Shafik "appreciates the efforts of those working alongside her on the long road ahead to heal our community."
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