Officials received reports of a fire on the 19th floor of the 35-story apartment building located at 221 E. 122nd St. between Third and Second avenues just before 7 p.m.
Twenty units and 78 fire and EMS personnel responded to the fire.
Officials say an unidentified 72-year-old individual was killed, and one firefighter suffered minor injuries.
The fire was placed under control just after 8 p.m.
Fire Marshals are investigating the cause of the deadly fire.
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