Firefighters raced to the site of a four-alarm fire off the Grand Concourse just after midnight.
FDNY crews extended several ladders from engine trucks as they battled the blaze from above.
Three frozen hydrants hindered their progress as they worked to get the fire under control.
The fire burned through the the top floor and cockloft of the apartment building, leaving visible damage and multiple blown-out windows.
Firefighters pulled two people, an 88-year-old man and a 74-year-old woman, to safety. The two residents are in stable condition.
The cause of the fire is still under investigation.
The American Red Cross is working to help displaced residents.
Displaced residents can seek help at the reception center at P.S./I.S. 218, entering at 167th and Walton.
At the reception center, residents can register for Red Cross recovery assistance and access a safe, warm place to wait for additional information about the building.
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