Many activists were detained after unsuccessfully trying to block Second Avenue.
The NYPD says 48 summonses were issued for disorderly conduct.
The protests came amid President Donald Trump's combative speech to the United Nations General Assembly on Tuesday morning, criticizing the international body while touting the work of his administration.
Trump spared no criticism, beginning with his predecessor former President Joe Biden before taking aim at world leaders on everything from migration to the Russia-Ukraine war.
The president then turned his attention the United Nations, accusing the organization of ignoring conflicts around the world that he helped solved and not living up to its promise.
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