It happened just after 9 p.m. Saturday at 34th Street near Sixth Avenue.
One of the victims suffered severe head injuries. Another victim is in stable condition.
The driver of the vehicle was also taken to the hospital for injuries.
A scooter was found on the ground. It is not clear whether the driver caused the crash or was a victim.
The investigation is ongoing.
ALSO READ | MTA stops construction on Second Avenue subway amid congestion pricing pause
MTA stops Second Avenue subway expansion construction amid congestion pricing pause
----------
* Get Eyewitness News Delivered
* More Manhattan news
* Send us a news tip
* Download the abc7NY app for breaking news alerts
* Follow us on YouTube
Submit a tip or story idea to Eyewitness News
Have a breaking news tip or an idea for a story we should cover? Send it to Eyewitness News using the form below. If attaching a video or photo, terms of use apply.