The FDNY said the fire broke out around 4:50 p.m. at the high-rise hotel located between West 53rd Street and Sixth Avenue.
Officials said the fire was located in a mechanical machine room in the basement.
Twenty-five units and 106 fire and EMS personnel responded to the scene.
No injuries were reported, and the fire was placed under control just after 6 p.m.
FDNY fire marshals are investigating the cause.
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