Firefighters battled the intense flames in the bitter cold at a building on Pacific Avenue around 4 a.m.
The two-story building contains a pizzeria and a cigar store on the ground floor and three apartments above.
Officials say there was a heavy fire from the pizzeria that went into the apartments and into the cockloft, causing the roof to start collapsing.
Crews had to saw through the roof of the building to get a better angle while trying to contain the flames.
Residents say the entire building had been recently renovated. Firefighters suspect the blaze started on the first floor but have not determined the cause.
So far there were no reports of any injuries.
The Red Cross is assisting with relocating two adults, one child and one dog.
The fire chief said this was one of 17 structure fires they have tackled in the city in the past two and a half weeks, which may be a record. But he said his men and women are up to the task.
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