The crash happened around 3:45 a.m. on Saturday on the Major Deegan Expressway near West Fordham Road.
According to the NYPD, a 39-year-old man was driving southbound on the expressway when he was struck by a black Mercedes Benz sedan from behind. Officials say the driver of the Mercedes Benz sedan got out of the vehicle and fled the scene on foot.
First responders transported the victim in critical condition to St. Barnabas Hospital, where he later died.
All southbound lanes on the Major Deegan Expressway were closed at Fordham Road as officers investigated the scene.
Authorities are trying to determine what led up to the crash.
----------
* Get Eyewitness News Delivered
* More Manhattan news
* Send us a news tip
* Download the abc7NY app for breaking news alerts
* Follow us on YouTube