The incident happened around 1:30 a.m. in the vicinity of Exit 37 in North Hills.
Authorities say 25-year-old Vincent Messina, of Dix Hills, was observed by a Nassau County Highway Patrol Officer driving a 2013 Smart car eastbound in the westbound lanes.
A car stop was conducted, and the investigation revealed Messina was intoxicated.
He was placed under arrest without incident.
No injuries were reported.
Messina is charged with reckless endangerment, reckless driving, driving while intoxicated, driving and other vehicle and traffic law violations.