Police said a driver who 'failed to navigate the road' struck two males as they were crossing the street.
A 51-year-old man was taken to NYC Health + Hospitals/Harlem in critical condition.
The second victim, also a 51-year-old male, was taken to NewYork-Presbyterian Hospital where he was pronounced dead.
The driver of the vehicle remained on scene and was taken to NYC Health + Hospitals/Metropolitan where he's expected to survive.
A woman said the crash was so loud, she heard it in her apartment.
"I was sitting in my living room and all of a sudden I heard a big bang. It was so hard. And when I came over to the window all I could see is people trying to get him out and they laid him on the ground," said an eyewitness named Gloria.
Surveillance video shows a woman pushing a shopping cart, pausing before crossing First Ave. That's when a white sedan appears to mount a curb and crashes into the cart and then the car hits a parked car which then hits two men.
Neighbors who knew the victim said he had lived in the area his whole life.
"We did homework, He comes from a long way. There were things, but my baby changed, he tried to do the right thing. He was a nice guy, he'd make you laugh all the time," a neighbor said.
"I was very sick I had cancer, and he used to make me laugh, and he would say come and visit and sit down and watch TV with me," a neighbor said.
The second person struck was also seriously hurt and is in critical condition
The investigation is ongoing. It is not clear if the driver will be charged.
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