At 2:22 p.m., officers responded to a report of a stabbing at St. Nicholas Avenue and 128th Street.
Upon arrival, police found a man who'd been stabbed multiple times.
The victim was taken to Harlem Hospital where he was pronounced dead.
Police are searching for the suspect, who is described as a roughly 300-pound man, last seen wearing a black t-shirt and shorts.
There are no arrests yet, and the investigation is ongoing.
***This story is developing and will be updated as new information becomes available.***
----------
* Get Eyewitness News Delivered
* More Manhattan news
* Send us a news tip
* Download the abc7NY app for breaking news alerts
* Follow us on YouTube