The worker's construction vehicle was in the westbound lanes of West Houston Street near Thompson Street when the box-truck driver hit his truck at around 6 a.m.
The worker fell from the boom truck on impact.
The driver did not stop, and was last seen moving westbound, headed toward the Holland Tunnel.
The injured man was taken to the hospital and is in stable condition.
The investigation is ongoing, and no arrests have been made.
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