A Medford home on Northfleet Lane connected with a "recent spike in drug overdoses" was searched recently, according to the Suffolk County Police Department.
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It has been linked to five fatal overdoses, officials said.
Investigators seized four illegal weapons, heroin and fentanyl, crack cocaine as well as other narcotics, and nearly $10,000 in drug money.
Suffolk County Police Commissioner Timothy Sini said this is not about arresting drug dealers, but about taking lethal products off the street.
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The four suspects are facing drug and illegal weapons charges, police said.
Eleven narcotics search warrants have been executed in Suffolk County so far this June.