It happened in the southbound lanes of Routes 1 and 9 near Duncan Avenue.
Police say two cars were involved in the crash.
At least one of those cars slammed into a wall, leaving the vehicle nearly unrecognizable.
3 people hurt in car accident on Routes 1 & 9
The victims were taken to nearby Jersey City Medical Center. The status of their condition has not yet been revealed.
All lanes in the northbound and southbound lanes have been closed in the area.
The Hudson County Prosecutor's Office has taken over as lead investigators of the crash.
Meanwhile, traffic has been diverted off the roadway and onto the local streets in Jersey City.
For drivers heading into New York City, consider alternate routes.
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