It happened around 8 p.m. on Route 52 in Liberty.
Police say the two teens were driving in a car when they collided with a pickup truck on the road.
The driver of the car, 17-year old Hanna Reggio, died after she was transported to Westchester Medical Center.
Joseph Young, 15, who was the passenger, died at Garnet Catskill Hospital, police say.
The 57-year-old driver of the pickup truck was treated for his injuries and released from the hospital.
Authorities are trying to determine what led up to the crash.
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