The flames erupted on the fourth floor of a five-story building on West 88th Street between Amsterdam and Broadway just after 9 p.m. on Saturday.
The 72-year-old man was found unconscious and unresponsive inside the apartment and was pronounced dead at Mount Sinai Morningside.
The firefighters were treated for minor injuries.
A second person is being evaluated as a precaution.
The cause of the fire remains under investigation.
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