Authorities say the first stabbing happened around 7:20 p.m. in front of 453 West 50th Street in Hell's Kitchen.
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They say a 28-year-old male was stabbed in the back during an unprovoked attack.
He was taken to Roosevelt Hospital, where he's listed in stable condition.
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Police say the second stabbing happened just before 8 p.m. in front of 501 West 47th Street.
In that incident, a 27-year-old woman was stabbed in the chest during an unprovoked attack.
She was transported to Roosevelt Hospital, where she's listed in stable condition.
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Both victims were unknown to each other.
Police took a suspect into custody at the Midtown North Precinct in connection with the first incident and are working to link him to the second.
They described the suspect as a man in his 40's, with blonde hair, last seen wearing a yellow shirt and tan shorts.
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