It happened just after 2:30 p.m. at 2680 Frederick Douglass Blvd.
Hamid Thomas, 32, was shot in the torso and left arm.
A 40-year-old woman suffered a graze wound to the lower back. She appeared to be a bystander and realized she was shot.
They both were taken to Harlem Hospital, where Thomas succumbed to his injuries. The woman was in stable condition and is expected to be okay.
The suspect is described as a male wearing a black hooded sweatshirt and a black ski mask who fled eastbound toward 7th Avenue.
No arrests have been made and the investigation is ongoing.
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