It happened just after 2:30 p.m. at 2680 Frederick Douglass Blvd.
An unidentified man in his 30s was shot in the torso and left arm.
A 40-year-old woman suffered a graze wound to the lower back. She appeared to be a bystander and realized she was shot.
They were both taken to Harlem Hospital where they are expected to be OK.
The suspect is described as a male wearing a black hooded sweatshirt and a black ski mask who fled eastbound toward 7th Avenue.
No arrests have been made and the investigation is ongoing.
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