The crash happened just after 5:30 a.m. on Ninth Avenue between West 54th and West 55th streets.
Police say the 66-year-old man was crossing Ninth Avenue mid-block when he was struck by a USPS truck.
The driver did not remain at the scene, according to police.
The victim was taken to an area hospital, where he was pronounced dead.
No arrests have been made.
The NYPD Highway Collision Investigation Squad is investigating.
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