Police say the victim was stabbed just before midnight at the Boulevard Homeless Shelter at 2027 Lexington Avenue in East Harlem.
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The 62-year-old victim was found with a stab wound to the neck. He was unresponsive and later pronounced dead at the scene.
Pursuant to the investigation, police have identified the suspect as 21-year-old Anthony White.
There have been no arrests.
Anyone with information in regards to this incident is asked to call the NYPD's Crime Stoppers Hotline at 800-577-TIPS.