Firefighters responded to 881 Fifth Ave. between 38th and 39th streets just after 8:30 p.m. for a report of a fire.
FDNY officials say heavy fire was found on the second floor of the four-story building.
They say 13 people, including two firefighters and 11 civilians, suffered non-life-threatening injuries.
The fire was placed under control just after 9:20 p.m.
There's no word yet on the cause of the fire.
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