The twin-engine Beechcraft landed on the northbound side of the Thruway (I-87) between exits 22 and 23 in Albany.
The FAA says the pilot reported an engine issue.
Three people were on board the plane. Minor injuries were reported, according to FAA officials.
Emergency responders are on the scene.
Two lanes on the northbound side of I-87 were closed, according to New York State Police.
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