The accident happened on the western spur of the northbound Turnpike on the Newark/Jersey City border at about 8 a.m.
The tractor trailer ran off the roadway and jumped the guardrail there.
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The driver suffered a minor injury.
Two lanes of the roadway were blocked for the accident investigation and debris removal, causing traffic delays.
Eyewitness News viewer Andrea Baldwin shot video of the scene:
Tractor trailer accident