The large-scale strikes, conducted by the U.S. alongside partner forces, occurred around 12:30 p.m. ET, according to U.S. Central Command. The strikes hit multiple Islamic State targets across Syria.
Saturday's strikes are part of a broader operation that is part of President Donald Trump's response to the deadly ISIS attack that killed Sgt. Edgar Brian Torres-Tovar, Sgt. William Nathaniel Howard, and Ayad Mansoor Sakat, the civilian interpreter, in Palmyra last month.
"Our message remains strong: if you harm our warfighters, we will find you and kill you anywhere in the world, no matter how hard you try to evade justice," U.S. Central Command said in a statement Saturday.
The administration is calling the response to the Palmyra attacks Operation Hawkeye Strike. Both Torres-Tovar and Howard were members of the Iowa National Guard.
It launched Dec. 19 with another large-scale strike that hit 70 targets across central Syria that had IS infrastructure and weapons.