The attack happened around 3:40 a.m. on Saturday in the vicinity of East 92nd Street and First Avenue.
Police say the victim was inside her home when the suspect approached her, forcefully entered her residence and then sexually assaulted her before fleeing the scene.
First responders transported the woman to a nearby hospital in stable condition. The NYPD's Manhattan Special Victims Squad is investigating the incident.
Anyone with information about the attack is asked to call the NYPD's Crime Stoppers Hotline at 1-800-577-TIPS (8477).
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