FDNY officials said the fire was reported just before 6 p.m. at 598 W 191 St. between Audubon Avenue and St. Nicholas Avenue.
The fire was reported on the second floor of a six-story building, fire officials said.
One firefighter suffered minor injuries.
The American Red Cross said dozens of people have been put out of their homes due to the fire.
Their disaster action team responders are running care and comfort handing out blankets and water. They also have a warming bus for people while they wait to see if they can go back into their homes or need somewhere to stay.
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