The demonstrators started around 3 p.m. at Grand Central Terminal before packing the Port Authority Bus Terminal and Penn Station.
They then marched down to Greenwich Village.
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A large number of NYPD officers followed the demonstrators, resulting in several arrests at multiple locations. There's no word yet on the exact number of arrests or the charges.
At one point, actor Alec Baldwin somehow got caught up in the protest.
Video shows him being escorted by police after reportedly getting into a shouting match with protesters who wanted to know his stance on the war.
Actor Alec Baldwin escorted by police during pro-Palestinian rally
The march also disrupted some bus service, with several lines running with delays as protestors made their way along 42nd Street between 6th Avenue and 8th Avenue.
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