Pictures show the puppies and adult dogs found inside the vacant home on Mattison Avenue in Asbury Park.
The Monmouth County SPCA rushed in to treat the pups, which did not have access to food or water and had just one small window for fresh air.
One puppy did not survive, but the rest are now being cared for.
Anyone with information about the owner of the animals is urged to call the Monmouth County Animal Cruelty Hotline at (877) 898-7297.
Tipsters can remain anonymous.
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